TAK-259 hydrochloride ( TAK259 hydrochloride )

Catalog No. M10666 CAS No. 1192347-42-4

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Product Name

TAK-259 hydrochloride
Note

Research use only, not for human use.
Brief Description

A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.
Description

A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively; shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats.Other Indication Phase 1 Discontinued
Synonyms

TAK259 hydrochloride
Pathway

Angiogenesis
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

Other Indications
Indication

Other Disease

CAS Number

1192347-42-4
Formula Weight

410.69
Molecular Formula

C14H14Cl3N3O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC(Cl)=CN(CC2=CC(Cl)=CC=C2S(=O)(C)=O)C1=N)N.[H]Cl
Chemical Name

5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride

1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002.

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